Maternal obesity and high leptin levels prime pro-inflammatory pathways in human cord blood leukocytes.

Bernardo J Krause,Fabian A Vega-Tapia, Gustavo Soto-Carrasco, Isidora Lefever, Catalina Letelier,Claudia G Saez,Jose A Castro-Rodriguez

Placenta（2023）

引用 0|浏览5

暂无评分

摘要

Obesity in pregnancy is associated with a distinctive expression and DNA methylation profile of leptin-related genes in cord blood monocytes, meanwhile, leptin enhances the expression of pro-inflammatory cytokines upon stimulation with M1-skewing agents.

查看译文

关键词

Maternal obesity, Immune function, Neonatal monocytes, Epigenetics, Leptin, Inflammation

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要