Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets

Hannah Larsen,Daire Byrne,Hasan Tahsin Ozpolat, Aastha Chauhan,Shawn Bailey,Nicole Rhoads, Franklin Reed,Massiel Chavez Stolla, Raymond Adili,Michael Holinstat,Xiaoyun Fu,Moritz Stolla

BLOOD（2023）

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摘要

Deleting 12-LOX improves the post-transfusion function of stored murine platelets by increasing thromboxane generation through COX-1-dependent arachidonic acid metabolism. Future studies should determine the feasibility and safety of 12-LOX-inhibited platelets transfused to humans.

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关键词

stored platelets,post-transfusion

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