Engineered 3D Immuno-Glial-Neurovascular Human Brain Model.

Alice E Stanton,Adele Bubnys,Emre Agbas, Benjamin James, Dong Shin Park,Alan Jiang,Rebecca L Pinals, Nhat Truong,Anjanet Loon, Colin Staab,Liwang Liu,Oyku Cerit,Hsin-Lan Wen,Manolis Kellis,Joel W Blanchard,Robert S Langer,Li-Huei Tsai

bioRxiv : the preprint server for biology（2023）

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摘要

A novel patient-specific brain model with BBB, neuronal, immune, and glial components was developed, characterized, and harnessed to model Alzheimer's Disease-associated pathologies and genetic risk.

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