Risk management actions following genetic testing in the Cancer Health Assessments Reaching Many (CHARM) Study: A prospective cohort study.

Boya Guo,Sarah Knerr,Tia L Kauffman,Kathleen F Mittendorf,Erin Keast,Marian J Gilmore,Heather Spencer Feigelson,Frances L Lynch,Kristin R Muessig,Sonia Okuyama,Jamilyn M Zepp,David L Veenstra,Li Hsu,Amanda I Phipps,Sara Lindström,Michael C Leo,Katrina A B Goddard,Benjamin S Wilfond,Beth Devine

Cancer medicine（2023）

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摘要

Though the number of participants who received actionable risk management recommendations was small, our results suggest that implementing CHARM's risk assessment and testing model increased access to evidence-based genetic services and provided opportunities for patients to engage in recommended preventive care, without encouraging risk management overuse.

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关键词

genetic testing, genomic sequencing, health service utilization, hereditary breast and ovarian cancer, hereditary cancer, Lynch syndrome, underserved populations

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