Frequency of toll-like receptor 4 variants and association with treatment response in children with primary immune thrombocytopenia.

Heba A Ahmed,Eman M Fahmy,Elsayed Abdelkreem,Ekram A Mahmoud, Asmaa Nafady,Eman H Ahmed

Pediatric blood & cancer（2023）

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摘要

The presence of TLR4 p.Asp299Gly or p.Thr399Ile variant may be associated with ITP predisposition, chronicity, and non-response to upfront steroid therapy. These findings enhance our understanding of the complex pathophysiology of pITP with potentially important clinical implications.

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immune thrombocytopenia, predictive genetic testing, prognosis, single nucleotide polymorphism, toll-like receptor 4

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