Reduced neurite density index in the prefrontal cortex of adults with autism assessed using neurite orientation dispersion and density imaging.

Takashi Arai,Koji Kamagata,Wataru Uchida,Christina Andica,Kaito Takabayashi,Yuya Saito,Rukeye Tuerxun,Zaimire Mahemuti,Yuichi Morita,Ryusuke Irie,Eiji Kirino,Shigeki Aoki

Frontiers in neurology（2023）

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摘要

GBSS analysis was used to demonstrate the ability of NODDI metrics to detect GM microstructural alterations in adults with ASD, while no changes were detected using DTI and cortical thickness evaluation. Specifically, we observed a reduced neurite density index in the left prefrontal cortices associated with reduced empathic abilities.

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关键词

autism, diffusion-weighted imaging, diffusion tensor imaging, gray matter, neurite orientation dispersion and density imaging, neuronal loss, surface-based cortical thickness measurement

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