Impact of inactivated COVID-19 vaccination on female ovarian reserve: a propensity score-matched retrospective cohort study.

Jialyu Huang, Tianshu Guan,Lifeng Tian,Leizhen Xia,Dingfei Xu,Xingwu Wu,Lingling Huang,Mengyi Chen,Zheng Fang, Chaoyi Xiong,Liju Nie, Shuang Wang,Zengming Li,Yan Zhao,Qiongfang Wu

Frontiers in immunology（2023）

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摘要

Our study provides the first evidence that inactivated COVID-19 vaccination has no measurable detrimental effect on ovarian reserve, regardless of female age and vaccination interval. This reassuring finding adds to the safety evidence of COVID-19 vaccine in fertility, and should be useful to promote vaccine acceptance. Multicenter prospective cohort studies are needed to validate our conclusion.

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关键词

COVID-19, SARS-CoV-2, vaccine, anti-Mullerian hormone, ovarian reserve

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