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Eph receptor B6 shapes a cold immune microenvironment, inhibiting anti-cancer immunity and immunotherapy response in bladder cancer.

Xiaolong Jia,Dongxu Zhang,Cheng Zhou,Zejun Yan,Zhaohui Jiang,Liping Xie,Junhui Jiang

Frontiers in oncology（2023）

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Abstract
This study comprehensively investigated the immunological effects of Eph receptor/EFN ligand family genes pan-cancer, and specially identified the immunosuppressive role of EPHB6 in BLCA. Furthermore, EPHB6 may predict the molecular subtype and prognosis of BLCA, and serve as a novel therapeutic target to improve the sensitivity of immunotherapy.
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Key words
bladder anti-cancer,immunotherapy response,cold immune microenvironment,immunity
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