Intrathecal umbilical cord mesenchymal stem cells injection alleviates neuroinflammation and oxidative stress in the cyclophosphamide-induced interstitial cystitis rats through the Sirt1/Nrf2/HO-1 pathway

Qiongqiong Gao,Yun Zhao, Ruixiang Luo,Minzhi Su,Chi Zhang,Cuiping Li,Bolong Liu,Xiangfu Zhou

Life sciences（2023）

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摘要

•Oxidative stress is involved in neuroinflammation of cystitis rat.•Sirt1 widely expressed in the nucleus of the spinal dorsal horn region in cystitis rat•Intrathecally injected umbilical cord mesenchymal stem cells for anti-neuroinflammation and oxidative stress in cystitis rat•Umbilical cord mesenchymal stem cells improving outcome of cystitis rat by upregulating Sirt1/Nrf2/HO-1 pathway

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关键词

Interstitial cystitis/bladder pain syndrome,Neuroinflammation,Oxidative stress,Human umbilical cord mesenchymal stem cells,Sirt1

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