Global research hotspots and frontier trends of epigenetic modifications in autoimmune diseases: a bibliometric analysis from 2012 to 2022

Background Epigenetics plays a significant role in the pathogenesis of autoimmune diseases (ADs) and has garnered considerable attention in related research fields. Recent studies have shown substantial progress in understanding the association between epigenetics and autoimmune diseases. However, there is a lack of comprehensive bibliometric analysis in this research area. Objective This article aims to present the current status and hot topics of epigenetic research in ADs from a bibliometric perspective, as well as explore the frontier hotspots and trends in epigenetic studies related to ADs. Methods This study collected 1,870 epigenetic records related to autoimmune diseases from the Web of Science Core Collection (WoSCC) database, spanning from 2012 to 2021. Analysis of regions, institutions, journals, authors, and keywords was conducted using CiteSpace, VOSviewer, and the R package "bibliometrix" to predict the latest trends in epigenetic research relevant to autoimmune diseases. Results The number of epigenetic publications related to autoimmune diseases has been increasing annually. The United States has played a major role in this field, contributing over 45.9% of publications and leading in terms of publication volume and citation counts. Central South University emerged as the most active institution, contributing the highest number of publications. Frontiers in Immunology is the most popular journal in this field, publishing the most articles, while the Journal of Autoimmunity is the most co-cited journal. Lu QJ is the most prolific author, and Zhao M is the most frequently co-cited author. "Immunology" serves as a broad representative of epigenetic research in ADs. Hot topics in the field of epigenetic modifications associated with autoimmune diseases include "regulatory T cells (Treg)," "rheumatoid arthritis," "epigenetic regulation," "cAMP-responsive element modulator alpha," "cell-specific enhancer," "genetic susceptibility," and "systemic lupus erythematosus." Furthermore, the study discusses the frontiers and existing issues of epigenetic modifications in the development of autoimmune diseases. Conclusion This study provides a comprehensive overview of the knowledge structure and developmental trends in epigenetic research related to autoimmune diseases over the past 11 years. The research findings summarize and clarify the forefront and future trends in studying the association between epigenetics and autoimmune diseases, serving as a reference for scholars engaged in exploring the relationship between epigenetics and autoimmune diseases Key Points This article presents the current status and hot topics of epigenetic research in ADs from a bibliometric perspective, as well as explore the frontier hotspots and trends in epigenetic studies related to ADs.Some potential future directions for epigenetic research in the context of autoimmune diseases include elucidating the mechanisms of epigenetic regulation in disease occurrence and development through annotation of specific genomic regions, with a greater emphasis on targeting microRNAs through mimics or inhibitors and cell-based therapies for the treatment of autoimmune diseases. These approaches hold great value and promise in regulating various aspects of human autoimmune diseases. It can be predicted that further collaboration between authors, institutions, and countries in the future will accelerate the development of epigenetic research related to autoimmune diseases ### Competing Interest Statement The authors have declared no competing interest. ### Clinical Trial N ### Clinical Protocols N ### Funding Statement This study is supported by the General Program of the National Natural Science Foundation of China (Grant No. 82074329), Summary of Experience in Characteristic Diagnosis and Treatment of Traditional Chinese Medicine and Inheritance and Research of Academic Thought (Grant No. 030054070), the Inheritance and Innovation Project of Traditional Chinese Medicine (Grant No. 008080022), and the Inheritance Project of Academic Thoughts of Famous TCM Doctors (Grant No. 003109011007). ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Not Applicable The details of the IRB/oversight body that provided approval or exemption for the research described are given below: This research data comes from the database and does not require ethical proof I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Not Applicable I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Not Applicable I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Not Applicable All relevant data are within the manuscript and its Supporting Information files. N