Mesenchymal stem cells differentiate to retinal ganglion-like cells in rat glaucoma model induced by polystyrene microspheres

Muhsin Eraslan,Eren Çerman, Süheyla Bozkurt,Deniz Genç, Aysın Tulunay Virlan, Cansu Subaşı Demir, Tolga Akkoç,Erdal Karaöz,Tunç Akkoç

Tissue and Cell（2023）

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Abstract

•Intravitreally injected rBM-MSCs to retinal ganglion-like cells•The frequency of Brn3a+GFP+ and CD11b+GFP+ cells notably increased in the G-MSC•MSCs promise hope for glaucoma as neuro-regeneration therapies.•NFP immunohistochemistry shows enlarged axonal fibers with intense staining.•GFAP immunohistochemistry demonstrated glial hypertrophy with increased expression in glial cells of the optic nerve.

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Key words

Flow cytometry,Glaucoma,Microbead,Neuro-protection,Neuro-regeneration,Polystyrene microsphere,Retinal ganglion cell,Stem cell

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