Multimodal imaging study of the 5-HT1A receptor biased agonist, NLX-112, in a model of L-DOPA-induced dyskinesia

Sarah Chaib,Benjamin Vidal,Caroline Bouillot,Ronan Depoortere,Adrian Newman-Tancredi,Luc Zimmer,Elise Levigoureux

NeuroImage. Clinical（2023）

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摘要

•Hemiparkinsonian (HPK) rats show a specific L-DOPA-induced brain metabolic pattern.•NLX-112 attenuated or reversed the cerebral effects of L-DOPA in dyskinetic HPK rats.•The predominant action of NLX-112 is mediated by 5-HT1A autoreceptors in the raphe.•This translational study supports development of NLX-112 as an anti-dyskinetic agent.

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关键词

Biased agonist,FDG,Levodopa-induced dyskinesia,Serotonin,fMRI

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