Three-component reaction of tert-butyl nitrite with indoles and halides: A facile and efficient synthesis of oxime ether derivatives

A mild and efficient one-pot method has been developed for the synthesis of oxime ether derivatives with up to 85% yield by employing tert-butyl nitrite (TBN) as nitrogen source, which occurs under room temperature and exhibits wide substrate scope. The single electron transfer mechanism and the cascade reactions approach have been confirmed.