Pyoderma gangrenosum and cytokine elevation associated with work-related injury

Background: Pyoderma gangrenosum is a rare condition usually associated with underlying diseases such as ulcerative colitis, inflammatory bowel disease, or rheumatoid arthritis. However, some cases may also be traced to trauma or surgical procedures. Objective: We reported a patient with pyoderma gangrenosum from work-related injury with abnormal cytokine elevation. Results: Skin biopsy of the ulcer showed diffuse cellular infiltration and increased expression of granulocyte colony-stimulating factor (G-CSF). Laboratory studies revealed elevated white blood cell levels and increases in the inflammatory markers interleukin-6 (IL-6) and G-CSF. Oral doses of prednisolone were effective in treating the ulcer. Conclusion: Measuring G-CSF and IL-6 levels may help facilitate earlier diagnosis of pyoderma gangrenosum, thereby resulting in more effective treatment. Keywords: Cytokines, immunosuppression, interleukins, pyoderma gangrenosum