Anticytokine Autoantibodies and Fungal Infections
JOURNAL OF FUNGI(2023)
摘要
Anticytokine autoantibodies (ACAAs) can cause adult onset immunodeficiencies which mimic primary immunodeficiencies and can present as refractory and severe fungal infections. This paper provides an overview of the role of innate immunity, including key cytokines, in fungal infections and then describes four clinical scenarios where ACAAs are associated with severe presentations of a fungal infection: (1) Talaromyces marneffei infection and anti-interferon-?, (2) histoplasmosis and anti-interferon-?, (3) Cryptococcus gattii infection and anti-GM-CSF, and (4) mucocutaneous candidiasis and anti-IL-17A/F (IL-22). Testing for ACAAs and potential therapeutic options are discussed.
更多查看译文
关键词
anticytokine autoantibodies, talaromycosis, cryptococcosis, histoplasmosis, chronic mucocutaneous candidiasis, anti-interferon-& gamma, antibodies, anti-GM-CSF antibodies, anti-IL-17/22 antibodies
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要