Metabolome analysis for host–microbiota interactions

Gut of human comprises a large number of symbiotic microbes that are essential for the maintenance of human health. The complex interaction taking place between the microbiota and the host is a challenging aspect for the development of treatment for various types of diseases such as microbiota dysbiosis. At present times, the flux balance uses the genome-scale reconstruction of various types of metabolic network. This helps in the determination of distribution of metabolome flux, thereby representing the metabolism of bacterium within the metabolic environment like that of the gut. Various simulations can be used in understanding the change in the microbiota with the effect of various types of dietary components. Thus, this chapter would focus on the various metabolome analysis in the establishment of host–microbiota interactions, thereby aiming in the maintenance of healthy human system.