Sulforaphane attenuates glycoprotein VI-mediated platelet mitochondrial dysfunction through up-regulating the cAMP/PKA signaling pathway in vitro and in vivo

Xinyu Zhou,Xinhui Huang,Chunting Wu,Yongjie Ma,Weiqi Li, Jinqiu Hu,Rong Li,Fuli Ya

Food & Function（2023）

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摘要

Treatment of SFN in human platelets or 12-week supplementation of SFN-enriched BSE in mice attenuates GPVI-mediated mitochondrial dysfunction, apoptosis and activation, which depends on decreasing PDE3A activity and up-regulation of the cAMP/PKA pathway.

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关键词

platelet mitochondrial dysfunction,glycoprotein,vi-mediated,up-regulating

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