Chiral phosphoric acid-catalyzed chemo and enantioselective 1,2-addition of isatin-derived β,γ-unsaturated α-ketoesters with 4-aminoindoles at the C7 position

The chemo and enantioselective 1,2-addition of isatin-derived β,γ-unsaturated α-ketoesters with indoles at the C7 position was described. Some of the products showed high in vitro cytotoxicity towards several human cancer cell lines.