Catalytic Asymmetric Addition Of Diorganozinc Reagents To Pyrazole-4,5-Diones And Indoline-2,3-Diones
CHEMISTRY-A EUROPEAN JOURNAL(2021)
Abstract
The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.
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Key words
chiral amino alcohol, diorganozinc addition, indoline-2, 3-diones, pyrazole-4, 5-diones
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