Alcohol and caffeine synergistically induce spontaneous ventricular tachyarrhythmias: ameliorated with dantrolene treatment.

Youhua Zhang, Christopher Kim, Nawal Wasif,Ying Li,Yuan Huang,Satoru Kobayashi,Lars Udo-Bellner,Randy Stout,Kaie Ojamaa

Heart Rhythm O2（2023）

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摘要

Co-consumption of caffeine and binge drinking synergistically promote spontaneous ventricular tachyarrhythmias in rats. Dantrolene treatment can decrease alcohol-enhanced Ca sparks in vitro and prevented alcohol and caffeine induced ventricular tachyarrhythmias in vivo.

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关键词

Alcohol, Caffeine, Arrhythmogenesis, Ventricular tachyarrhythmia, Bidirectional ventricular tachycardia, Dantrolene

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