Bioactive membranes of tricalcium phosphate and hydroxyapatite containing manganese for bone regeneration

In this study, we produced bioactive ceramic membranes of tricalcium phosphate (TCP) and hydroxyapatite (HA) incorporated with manganese (Mn) with osteogenic and antibacterial properties for applications in bone regeneration. Membranes were prepared by tape casting technique using PVA as a binder between molecules. The incorporation of manganese favors the reticulation of the membranes, providing more excellent resistance in aqueous media. Furthermore, the HA-Mn membrane exhibits the lowest optical density values and, therefore, the most significant difference from the negative control, presenting the lowest cellular viability. Between the membranes without manganese, HA shows the highest efficiency in improving cellular viability. Through bioactivity analysis, we observed that the TCP-Mn membrane presents the most significant formation of amorphous calcium phosphate precipitates, making the material more bioactive. Thus, our results become fascinating for applications in biomaterials.