CancerX: A national public-private partnership to boost innovation in the fight against cancer

e13637 Background: In early 2022, President Biden reignited the Cancer Moonshot, setting new national goals to cut the death rate from cancer by at least 50% over the next 25 years and improve the experience of people and their families living with and surviving cancer. In its first year, the reignited Cancer Moonshot announced over 25 new programs, policies, and resources in pursuit of these goals. In February 2023, to mark the one-year anniversary of the new national goals, the Cancer Cabinet – the expert and interagency body responsible for setting the Cancer Moonshot agenda across government agencies – announced three new actions, including the launch of CancerX - a public-private partnership (PPP) to act as a national accelerator to boost innovation in the fight against cancer. Methods: Leveraging foundational work of Moffitt Cancer Center, the U.S. Department of Health and Human Services (HHS), the Digital Medicine Society (DiMe), and Moffitt Cancer Center have come together to establish and lead CancerX as an open, collaborative public private partnership effort to rapidly accelerate the pace of cancer innovation in the US. This builds on momentum of prior successful multi-stakeholder collaborations led by these founders to advance digital innovation to reduce the incidence and burden of cancer for all people. This multi-stakeholder success will characterize CancerX, with additional organizations driving innovation in the fight against cancer participating across initiatives. Results: To speed the development and optimize the impact of innovative solutions across the continuum of cancer care – including prevention, detection, treatment, and transitions in care – CancerX is comprised of three key initiatives: 1) Pre-competitive evidence generation: a rolling series of multi-stakeholder efforts will develop evidence, best practices, toolkits, and value models to drive the success of the mission. 2) Accelerator: This program will provide mentorship, education, and exposure to funding and clinical partnership opportunities to a start-up cohort aligned with the mission. 3) Demonstration projects: These implementation projects will pilot novel, mission-aligned approaches to demonstrate their value and sustainability for scale to drive broad adoption. Conclusions: CancerX provides a structure for organizations whose missions are aligned with the Cancer Moonshot goals to rapidly advance innovative solutions for success at scale. Through a multi-pronged approach focused on 1) commoditizing best practices and aligning incentives, 2) coordinating access to research, mentorship, resources, and other collaborative opportunities, and 3) demonstrating success in practice to drive broad adoption, this PPP will reduce the incidence and burden of cancer for all people.