Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation

Herein, a straightforward synthetic approach for the construction of phenanthridin-6-(5H)-one skeletons is disclosed. The developed protocol relies on palladium catalysis, providing controlled access to a range of functionalized phenanthridin-6-(5H)-ones in 59-88% yields. Furthermore, plausible reaction pathways are proposed based on mechanistic experiments.