Social determinants of adult health outcomes in Sickle cell disease: a scoping review protocol

Objective To summarize the evidence and identify gaps in the literature related to the impact of social factors on health outcomes across the life course for persons with Sickle Cell Disease. Introduction Sickle cell disease (SCD) is a group of genetic diseases where abnormal hemoglobin is associated with recurrent complications across the life course which results in increased morbidity or death. The social determinants of health may impact health outcomes throughout the life course of these individuals. Better understanding of the effect that these factors and their complications have may influence management approaches both medically and socially to improve quality of life. Inclusion criteria All studies published in English between 1973 and 2023 of persons of all ages living with SCD (SS, SC, SB SB+), examining factors related to the social determinants of health will be included. Conference abstracts, editorials and opinion papers will be excluded. Methods Methods proposed by the Joanna Briggs Institute (JBI) and by Westphaln and colleagues in 2021 will be used. The electronic databases Academic Search Ultimate (EBSCO), Open Science Framework and PubMed will be searched using a pre-specified search strategy developed with stakeholder input. All citations will be reviewed by two independent reviewers with disagreements adjudicated by a third reviewer. The screening process will be reported in a Preferred Reporting Items for Systematic Reviews Extensions for Scoping reviews (PRISMA-ScR) flow diagram. The Rayyan software will be used to manage the review process. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study did not receive any funding ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethical approval was obtained from the Mona Research Ethics Committee (MREC) at the University of the West Indies (# CREC-MN.0154, 2022/2023). I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors