Mouse Models of Henipavirus Infection.
Methods in molecular biology (Clifton, N.J.)(2023)
摘要
The Nipah and Hendra viruses, belonging to henipavirus genus, are recently emerged zoonotic pathogens that cause severe and often fatal, neurologic, and/or respiratory diseases in both humans and various animals. As mice represent a small animal model convenient to study viral infections and provide a well-developed experimental toolbox for analysis in immunovirology, we describe in this chapter a few basic methods used in biosafety 4 level (BSL4) conditions to study henipavirus infection in mice.
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关键词
BSL4,Clinical scoring,Emerging infection,Henipavirus,Murine model,Seroneutralization,Transgenic mice,Type I interferon
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