Kevin Lafferty and the lymphocyte costimulator: theory and practice in Canberra.
Immunology and cell biology（2023）
摘要
Between 1969 and 1983 the lab of Kevin Lafferty in Canberra developed the concept of the T-cell "costimulator," an essential second signal for activation. A great deal of the work appeared in this journal before it was known as Immunology & Cell Biology (ICB). As part of the 100-year anniversary of the journal, I offer a personal reflection on Kevin's legacy and impact.
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关键词
Adaptive immunity,antigen presentation,cellular immunity,clonal selection,transplant immunology
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