Decreased myelin-related gene expression in the nucleus accumbens during spontaneous neonatal opioid withdrawal in the absence of long-term behavioral effects in adult outbred CFW mice.

Kristyn N Borrelli, Kelly K Wingfield,Emily J Yao,Catalina A Zamorano,Katherine D Sena,Jacob A Beierle, Michelle A Roos,Huiping Zhang,Elisha M Wachman,Camron D Bryant

bioRxiv : the preprint server for biology（2023）

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摘要

We replicated some NOWS model traits via 1x-daily morphine (P1-P14).We found a downregulation of myelination genes in nucleus accumbens on P15.There were no effects on learning/memory or reward sensitivity in adults.

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关键词

Opiate, Neonatal abstinence syndrome, Neonatal opioid withdrawal syndrome, Swiss webster, RNA-seq, Opioid use disorder, ICSS

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