Adipocyte-Derived Exosomal NOX4-Mediated Oxidative Damage Induces Premature Placental Senescence in Obese Pregnancy.

Yuelan Tao,Wei Chen,Hongbing Xu,Jiacheng Xu,Huan Yang,Xin Luo,Miaomiao Chen,Jie He,Yuxiang Bai,Hongbo Qi

International journal of nanomedicine（2023）

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摘要

In obesity, adipose tissue can secrete exosomes containing NOX4 which can be delivered to trophoblast resulting in severe DNA oxidative damage and premature placental senescence, ultimately leading to adverse pregnancy outcomes.

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关键词

NADPH oxidase 4,adipose tissue,exosome,maternal obesity,oxidative damage,placental premature senescence

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