Fiber-Specific White Matter Alterations in Parkinson's Disease Patients with GBA Gene Mutations.

Christina Andica,Koji Kamagata,Wataru Uchida,Yuya Saito,Kaito Takabayashi,Akifumi Hagiwara,Haruka Takeshige-Amano,Taku Hatano,Nobutaka Hattori,Shigeki Aoki

Movement disorders : official journal of the Movement Disorder Society（2023）

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摘要

We report reduced fiber-specific WM density and bundle cross-sectional size in patients with GBA-PD, suggesting neurodegeneration linked to glucocerebrosidase deficiency, α-synuclein accumulation, and poorer cognition and motor functions. Conversely, patients with iPD showed increased fiber bundle size, likely because of WM reorganization. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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关键词

GBA gene mutations,Parkinson's disease,fixel-based analysis,neurodegeneration,neuroplasticity

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