Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension.
Vascular pharmacology（2023）
Abstract
Increase in MMP-2 activity proteolyzes type I collagen in the aortas of 2K1C rats and contributes to activate FAK and induces VSMC proliferation during the initial phase of hypertension.
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Key words
Collagen,Focal adhesion kinase,Matrix metalloproteinase-2,Vascular smooth muscle cells
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