Sudden Unexpected Death in Epilepsy and Respiratory Defects in a Mouse Model of DEPDC5-related Epilepsy.

Hsin-Yi Kao,Yilong Yao,Tao Yang,Julie Ziobro, Mary Zylinski,Mohd Yaqub Mir,Shuntong Hu,Runnan Cao,Nurun Nahar Borna, Rajat Banerjee,Jack M Parent,Shuo Wang,Daniel K Leventhal,Peng Li,Yu Wang

Annals of neurology（2023）

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Abstract

Depdc5 deletion in excitatory neurons is sufficient to cause DEPDC5-related epilepsy and SUDEP. Ictal apnea and respiratory dysregulation play critical roles in SUDEP. Our study also provides a novel mouse model to investigate the underlying mechanisms of DEPDC5-related epilepsy and SUDEP. This article is protected by copyright. All rights reserved.

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