Enhancing metabolite coverage in MALDI-MSI using laser post-ionisation (MALDI-2).

J C McKinnon,H H Milioli, C A Purcell,C L Chaffer, B Wadie,T Alexandrov,T W Mitchell,S R Ellis

Analytical methods : advancing methods and applications（2023）

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摘要

Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) of metabolites can reveal how metabolism is altered throughout heterogeneous tissues. Here negative ion mode MALDI-MSI has been coupled with laser post-ionisation (MALDI-2) and applied to the MSI of low molecular weight (LMW) metabolites (更多

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metabolite coverage,laser,maldi-msi,post-ionisation

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