Endoscopic ultrasound-guided radiofrequency ablation for solid pseudopapillary neoplasm of the pancreas.

A solid pseudopapillary neoplasm (SPN) is considered a low-grade malignant neoplasm, more often composed of both solid and cystic components with pseudopapillary areas but predominantly solid in 15 % of cases [1]. It is estimated to account for 1 % to 3 % of all pancreatic tumors [2]. Immunostaining of SPNs for beta-catenin is specific [3]. The natural history of these lesions is unknown, but the malignant potential is demonstrated especially in large lesions. The gold standard therapy is surgical resection. Nonetheless, an alternative such as endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA), which is less invasive [4], should be discussed, especially for young patients with small lesions [5]. All cases of SPN seen and treated with EUS-RFA between 2018 and 2020 were reviewed (IRB 00010835).