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Association of CDX2 and mucin expression with chemotherapeutic benefits in patients with stage II/III gastric cancer.

Xianchun Gao,Weili Han, Ling Chen,Hongwei Li,Fenli Zhou,Bin Bai,Junya Yan,Yong Guo, Kun Liu,Wenjiao Li,Renlong Li, Qiangqiang Yuan,Jiehao Zhang,Yuanyuan Lu,Xiaodi Zhao,Gang Ji,Mengbin Li,Qingchuan Zhao,Kaichun Wu,Zengshan Li,Yongzhan Nie

Cancer medicine（2023）

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Abstract
Negative expression of CDX2 is an independent risk factor for survival in stage II/III GC, but subsequent adjuvant chemotherapy is able to compensate for this unfavorable effect. Therefore, active chemotherapy is more urgent for patients with negative CDX2 expression than for patients with positive CDX2 expression.
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Key words
adjuvant chemotherapy,CDX2,gastric cancer,immunohistochemistry,mucin
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