Harmonization and standardization of biofluid-based biomarker measurements for AT(N) classification in Alzheimer's disease.

Chiara Giangrande,Vincent Delatour,Ulf Andreasson,Kaj Blennow,Johan Gobom,Henrik Zetterberg

Alzheimer's & dementia (Amsterdam, Netherlands)（2023）

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摘要

The AT(N) biomarker system allows stratifying AD patients on the basis of biomarker profiles.Fluid biomarker measurements often present an important between-laboratory variation preventing the establishment of standardized cutoff values.Overview on the standardization initiatives involving the fluid biomarkers currently included in the AT(N) framework.

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关键词

Alzheimer's, AT(N), early diagnosis, fluid biomarkers, reference materials, reference measurement procedures, standardization

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