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Molecular Status of BRAF Mutation in Epithelial Ovarian Cancer: An Analysis of 57 Cases in the Northeast of Iran.

Amirhossein Jafarian,Masoumeh Jafaripour,Masoumeh Gharib,Maryam Salehi,Nema Mohamadian Roshan,Sare Etemad, Khatoone Mirshekar,Maryam Sheikhi, Masoumeh Heidari, Behnaz Ahmadian,Zahra Khoshnegah,Hossein Ayatollahi,Payam Siyadat

Iranian journal of pathology（2023）

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Abstract
The mutation is most frequent in borderline tumors but not in invasive serous carcinomas. It seems that 2 different pathways exist for the development of ovarian epithelial neoplasms: one for borderline tumors and the other for high-grade invasive carcinomas. Our study supports this hypothesis. The mutation is rare in mucinous neoplasms.
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ovarian cancer,braf mutation
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