Timing of hormone therapy and its association with cardiovascular risk and metabolic parameters in 4-vinylcyclohexene diepoxide-induced primary ovarian insufficiency mouse model.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology（2023）
摘要
On-time, continuous E2 treatment immediately after a biologic estrogen deprivation event significantly reduced metabolic and cardiovascular risks in young, pre-menarche female mouse models of POI, confirming decreased serum levels of pro-inflammatory cytokines.
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关键词
Hormone therapy, timing hypothesis, primary ovarian insufficiency, metabolic syndrome, cardiovascular disease, 4-vinylcyclohexene diepoxide, >
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