Disruption of Ebola NP0VP35 Inclusion Body-like Structures reduce Viral Infection

Chao Wu,Nicole D. Wagner,Austin B. Moyle,Annie Feng,Nitin Sharma,Sarah H. Stubbs,Callie Donahue,Robert A. Davey,Michael L. Gross,Daisy W. Leung,Gaya K. Amarasinghe

Journal of Molecular Biology（2023）

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摘要

•In vitro purified Ebola eNP0VP35 spontaneously phase separates, likely seeding early stages of viral IB assembly.•Construct screening illuminates key interactions within phase separated droplets.•Ebola IBs are composed of eNP0VP35 complexes and other key viral and host components.•Perturbation of eNP0VP35 complex reduces viral IB formation and viral infection.

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关键词

Ebola,inclusion body,viral replication organelle,phase separation,biomolecular condensate

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