SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter.
Clinical and translational medicine(2023)
Abstract
Our results revealed an epigenetic mechanism associated with SIRT6 and Ero1α expression and highlighted the therapeutic potential of targeting the SIRT6-HIF1α/p300-Ero1α axis.
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Key words
endoplasmic reticulum stress,ischemia‒reperfusion injury,SIRT6
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