SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter.

Clinical and translational medicine(2023)

Cited 0|Views30
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Abstract
Our results revealed an epigenetic mechanism associated with SIRT6 and Ero1α expression and highlighted the therapeutic potential of targeting the SIRT6-HIF1α/p300-Ero1α axis.
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Key words
endoplasmic reticulum stress,ischemia‒reperfusion injury,SIRT6
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