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Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer.

Journal for immunotherapy of cancer(2023)

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Abstract
LMWH could enhance ACT and ICIs-based immunotherapy by increasing lymphocyte infiltration into tumors, especially cytotoxic CD8 T cells. These results indicate that combining LMWH with an immunotherapy strategy presents a promising and safe approach for CRC treatment, especially in MSS tumors.
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Key words
gastrointestinal neoplasms, lymphocytes, tumor-infiltrating, immunotherapy, adoptive, immune checkpoint inhibitors, tumor microenvironment
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