Fatty acid β-oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice.

Peng Wang,Rui Wei,Xiaona Cui,Zongzhe Jiang,Jin Yang,Lingyun Zu,Tianpei Hong

Journal of diabetes（2023）

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摘要

GCGR antagonism has a protective effect on CMECs and cardiac diastolic function in diabetic mice, and this beneficial effect may be mediated via inhibiting fatty acid β-oxidation and mitochondrial fusion in CMECs.

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