Sex-Specific Implant Fixation Can Reduce Revision Rates in Total Hip Arthroplasty: Evidence From the Swiss National Joint Registry

Background: Patient's sex is considered a risk factor for revision following primary total hip arthroplasty (THA), but sex -specific treatment guidelines are lacking. The purpose was to assess sex -specificity of risk factors for periprosthetic femoral fractures (PFFs) and aseptic stem loosening (ASL) in a nationwide register study. Methods: All uncemented and hybrid THAs for hip osteoarthritis registered in the Swiss National Joint Registry were considered. 86,423 THAs were analyzed. Comparable THA subsets for both sexes were obtained through propensity score matching (1:1). A sex -specific analysis of risk factors for early PFF or ASL was performed using recursive partitioning analyses. Results: In women, PFFs were most significantly associated with uncemented THA fixation (P < .0001) and age (P < .01, threshold: 70.5 years). The ASLs were solely associated with patient age of <65 years (P = .023). In men, PFFs were associated exclusively with an American Society of Anesthesiologists (ASA) score >2 (P = .026). The ASLs were not correlated to any of the potential risk factors analyzed. A mathematical simulation indicated that avoiding uncemented THA fixation in women >70.5 years of age decreased the number of revisions within the observational period by 21% in this subset and by 4.9% in the entire patient population. Conclusion: Uncemented THA should be avoided in women >70.5 years due to the increased risk of early PFF, while the mode of stem fixation did not influence revision risk in men. A sex -specific regimen for THA fixation has the potential to markedly reduce early THA revision rates. (c) 2023 Elsevier Inc. All rights reserved.