BRAFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

Aldo A. Acosta-Medina,Paul G. Kemps,Timo C. E. Zondag,Jithma P. Abeykoon,Jelske Forma-Borst,Eline C. Steenwijk,Elizabeth A. M. Feijen,Jop C. Teepen,N. Nora Bennani, Susan M. Schram,Mithun V. Shah,Caroline Davidge-Pitts,Matthew J. Koster,Jay H. Ryu,Robert Vassallo,W. Oliver Tobin,Jason R. Young,Surendra Dasari,Karen Rech,Aishwarya Ravindran

Blood（2023）

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摘要

In this retrospective study, BRAFmutation status did not correlate with disease extent or (event-free) survival in 156 adults with LCH. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers - which may be clonally related.

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langerhans cell histiocytosis,second cancers

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