Primary microcephaly gene CENPE is a novel biomarker and potential therapeutic target for non-WNT/non-SHH medulloblastoma.

Huangyi Fang, Yusong Zhang,Chengyin Lin, Zhenkai Sun, Wei Wen,Hansong Sheng,Jian Lin

Frontiers in immunology（2023）

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摘要

The expression of CENPE in non-WNT/non-SHH MB was positively correlated with poor prognosis. CENPE may affect tumor progression by regulating cell cycle, p53 pathway, and immune infiltration. Hence, CENPE is highly likely a novel biomarker and potential therapeutic target for non-WNT/non-SHH MB.

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关键词

microcephaly,novel biomarker,potential therapeutic target,non-wnt,non-shh

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