Integrated single cell and bulk sequencing analysis identifies tumor reactive CXCR6 + CD8 T cells as a predictor of immune infiltration and immunotherapy outcomes in hepatocellular carcinoma.

Xiaogang Li,Zheng Gao,Jiafeng Chen,Shanru Feng,Xuanming Luo,Yinghong Shi,Zheng Tang,Weiren Liu, Xin Zhang,Ao Huang,Qiang Gao,Aiwu Ke,Jian Zhou,Jia Fan,Xiutao Fu,Zhenbin Ding

Frontiers in oncology（2023）

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摘要

We constructed a comprehensive single cell and multi-omics landscape of immune infiltration in HCC, and delineated key genes and cellular populations regulating immune infiltration and immunotherapy response, thus providing insights into the mechanisms of immune infiltration and future therapeutic control.

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关键词

hepatocellular carcinoma, immune infiltration, single cell sequencing technology, biomarker, tumor reactive T cells, immunotherapy

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