Gemcitabine Inhibits the Progression of Pancreatic Cancer by Restraining the WTAP/MYC Chain in an m6A-dependent Manner.

Pei Cao,Weigang Zhang,Junyi Qiu,Zuxiong Tang,Xiaofeng Xue,Tingting Feng

Cancer research and treatment（2023）

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摘要

Our study confirmed that gemcitabine interferes with WTAP protein expression in PC, reduces m6A modification on MYC and RNA stability, thereby inhibiting the downstream pathway of MYC, and inhibits the progression of PC.

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