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Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension.

Xiaofei Zhou,Yuanqing Jiang,Yuewen Wang,Linge Fan,Yunhui Zhu,Yefeng Chen,Yiran Wang, Yingyi Zhu,Hongkun Wang,Zihang Pan,Zhoubin Li,Xiaolong Zhu,Ruizhe Ren,Zhen Ge,Dongwu Lai,En-Yin Lai,Ting Chen,Kai Wang,Ping Liang,Lingfeng Qin,Cuiqing Liu,Cong Qiu,Michael Simons,Luyang Yu

Circulation research（2023）

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Abstract
By maintaining endothelial mitochondrial homeostasis, deSUMOylation of FIS1 adaptively preserves pulmonary endothelial function against hypoxic stress and consequently protects against PH. The FIS1 deSUMOylation-SUMOylation transition in pulmonary endothelium is an intrinsic pathogenesis of hypoxic PH.
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Key words
endothelial cells, hypertension, pulmonary, hypoxia, mitochondria, sumoylation
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