Chiral bifunctional organocatalysts for enantioselective synthesis of 3-substituted isoindolinones
RSC advances(2023)
Abstract
A series of chiral bifunctional organocatalysts were prepared and used for enantioselective synthesis of 3-substituted isoindolinones from 2-formylarylnitriles and malonates through aldol-cyclization rearrangement tandem reaction in excellent yields and enantioselectivites (up to 87% yield and 95% ) without recrystallization. In this investigation, we found that chiral tertiary-amine catalysts with a urea group can afford 3-substituted isoindolinones both in higher yields (87% 77%) and enantioselectivities (95% 46% ) than chiral bifunctional phase-transfer catalysts.
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Key words
chiral bifunctional organocatalysts,enantioselective synthesis
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