On fine particulate matter and COVID-19 spread and severity: An in vitro toxicological plausible mechanism

S. Marchetti,M. Gualtieri,A. Pozzer, J. Lelieveld, F. Saliu, A.L. Hansell, A. Colombo, P. Mantecca

Environment international（2023）

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摘要

•PM2.5-driven increase in ACE2 as a contributing factor of SARS-CoV-2 infection.•SARS-CoV-2 exploits increased ACE2 to infect lung A549 cells.•PM and SARS-CoV-2 interplay determines the severity of the inflammatory responses.

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关键词

Particulate matter,SARS-CoV-2,Mode of action,ACE2,Inflammation,Early endosome

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