Vibrational spectroscopy methods for investigation of the animal models of glioblastoma multiforme

Karolina Olbrich,Zuzanna Setkowicz,Kamil Kawon,Mateusz Czyzycki,Natalia Janik-Olchawa,Ilaria Carlomagno,Giuliana Aquilanti,Joanna Chwiej

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy（2023）

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摘要

•Morphology and biomolecular composition of brain tissue change during glioblastoma multiforme growth.•Vibrational spectroscopy methods allow to follow biochemical alterations caused by tumor development.•Levels of lipids and compounds containing carbonyl groups are diminished within the area of glioma.•Glioblastoma multiforme growth causes changes in the secondary protein structure.•Observed biochemical abnormalities are characteristic for particular animal model of brain tumor.

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关键词

Glioblastoma multiforme (GBM),Animal models,Vibrational spectroscopy,Fourier transform infrared microspectroscopy (FTIR),Raman microscopy,X-ray fluorescence (XRF) spectrometry,Principal component analysis (PCA)

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